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7 Top Hotels in St Louis near Mercy South

Are you planning a trip to St. Louis and looking for a cozy spot near Mercy South? You're in luck! I’ve rounded up a list of the top 7 hotels that offer comfort and convenience for your stay in this vibrant city. Whether you’re visiting for work or just to explore, these accommodations promise a great experience. Let’s dive in and find the perfect place for you!

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Hampton Inn & Suites - Saint Louis South Interstate 55

Hampton Inn & Suites - Saint Louis South Interstate 55

Fairfield By Marriott Inn & Suites St Louis South

4318 Butler Hill Road | 2 mi (3.2km) to Mercy Hospital South

8.9Excellent
Fairfield by Marriott Inn & Suites St Louis South ImageFairfield by Marriott Inn & Suites St Louis South ImageFairfield by Marriott Inn & Suites St Louis South Image

Fairfield by Marriott Inn & Suites St. Louis South is a cozy 3-star hotel that promises a comfy stay just minutes from your adventures in St. Louis. With easy access to attractions, this hotel makes it an excellent choice for both work and play. Whether you’re heading out to visit the famous St. Louis Zoo or planning a fun day at Grant's Farm, this friendly spot has you covered.

The hotel features modern amenities that help you kick back after a day of exploring. Enjoy a refreshing dip in the pool or start your day with a delicious breakfast. Its welcoming vibe will make you feel right at home. The location offers plenty of options for food, fun, and entertainment nearby. Happy travels!

Holiday Inn Express & Suites - St. Louis South - I-55, An IHG Hotel

4250 Midamerica Lane | 2.1 mi (3.3km) to Mercy Hospital South

9.1Exceptional
Holiday Inn Express & Suites - St. Louis South - I-55, an IHG Hotel ImageHoliday Inn Express & Suites - St. Louis South - I-55, an IHG Hotel ImageHoliday Inn Express & Suites - St. Louis South - I-55, an IHG Hotel Image

If you're searching for a great place to stay near Mercy South in St. Louis, the Holiday Inn Express & Suites - St. Louis South - I-55 has got all your needs covered! Located in Mattese, this cheerful hotel features comfy, air-conditioned rooms equipped with free WiFi so you can easily stay connected. You’ll also find an indoor pool that's perfect for a little relaxation after your day’s adventures and a fitness center if you want to keep up with your workouts!

Each room comes with a desk and a flat-screen TV, plus a handy fridge to store your snacks. If you need anything while you’re here, the friendly 24-hour front desk is always ready to help. And when it’s time to wrap up the day, you can grab a tasty snack or a refreshing drink from the vending machines to enjoy while you kick back in your room. Enjoy your stay!

Hampton Inn & Suites - Saint Louis South Interstate 55

4200 MidAmerica Lane | 2.1 mi (3.4km) to Mercy Hospital South

9.1Exceptional
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The Hampton Inn & Suites - Saint Louis South Interstate 55 is a fantastic choice if you're staying near Mercy South. This hotel offers rooms with flat-screen TVs, microwaves, and refrigerators, making it easy to feel right at home. Start your day with a delicious breakfast buffet, and don't forget to pick up a newspaper to catch up on the latest news while you eat!

After a busy day, kick back and relax in the indoor pool or unwind in the spa bath. If you're looking to break a sweat, the fitness center is ready for you. Plus, there are plenty of handy amenities like a business center and dry cleaning services to make your stay stress-free. Enjoy your time here, and make some great memories!

Best Western St. Louis Inn

6224 Heimos Industrial Park Drive | 3.1 mi (5km) to Mercy Hospital South

7.5Good
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If you’re on the lookout for cozy places to stay near Mercy South in St. Louis, the Best Western St. Louis Inn should definitely be on your list! Located just off I-55, this hotel features comfy rooms equipped with plenty of modern perks, including free Wi-Fi. You’ll love starting your day with a hearty hot breakfast—nothing sets you up for some adventure like a delicious meal!

Once you’ve fuelled up, why not take a dip in the indoor pool or squeeze in a workout at the fitness center? In the area, you’ve got fun options galore! Explore the well-known Anheuser Busch Brewery, unleash your inner thrill-seeker at Six Flags St. Louis, or grab some goodies at South County Mall. Don’t forget to snap a pic at the iconic St. Louis Arch. Enjoy your stay and make some fantastic memories!

Comfort Suites St Louis - Sunset Hills

3654 S Lindbergh Blvd | 3.5 mi (5.6km) to Mercy Hospital South

9Exceptional
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If you’re searching for a welcoming place to stay near Mercy South in St. Louis, check out Comfort Suites St Louis - Sunset Hills! This lovely 3-star hotel is perfect for anyone looking for a comfortable spot. With cozy rooms that include a fridge and a sitting area, you can kick back and relax after a busy day. Plus, the friendly staff is available 24/7 to help with anything you need.

Start your morning right with a tasty buffet breakfast—it's an excellent way to fuel up for your adventures! If you’re up for it, take a refreshing dip in the indoor pool. And when it comes to exploring, you’re in luck! There are tons of exciting attractions nearby, so your trip is sure to be packed with fun. Enjoy your stay and create some wonderful memories in St. Louis!

La Quinta Inn & Suites By Wyndham St Louis Route 66

1580 South Kirkwood Road | 3.7 mi (6km) to Mercy Hospital South

7.7Good
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La Quinta Inn & Suites by Wyndham St Louis Route 66 is a fantastic pick for anyone looking to stay near Mercy South in St. Louis! This cheerful 3-star spot has everything you need for a comfortable and fun stay. With a fitness center, an indoor pool, and a hot tub, you can unwind and recharge after a day of adventures. Plus, the friendly staff is there around the clock to make sure you have everything you need.

Each room is cozy and has all the essentials, including a flat-screen TV, coffee maker, and free WiFi to keep you connected. Enjoy a delicious breakfast each morning, with a variety of tasty options to set you up for the day. Whether you're gearing up for some sightseeing or just want to chill out, La Quinta Inn & Suites is a wonderful home base for your St. Louis escapades!

Holiday Inn St Louis SW - Route 66, An IHG Hotel

10709 Watson Road | 3.7 mi (6km) to Mercy Hospital South

8.2Very Good
Holiday Inn St Louis SW - Route 66, an IHG Hotel ImageHoliday Inn St Louis SW - Route 66, an IHG Hotel ImageHoliday Inn St Louis SW - Route 66, an IHG Hotel Image

If you’re looking for a great hotel near Mercy South in St. Louis, the Holiday Inn St Louis SW - Route 66, an IHG Hotel, is a perfect choice! This cheerful 3-star hotel has a seasonal outdoor pool where you can cool off on warm days, a fitness center to help you stay active, and a cozy restaurant on-site. The friendly staff is always ready to assist you, ensuring you have a fantastic stay. Plus, you can kick back and enjoy a drink in the bar after a day of exploring!

Every morning, you can treat yourself to a scrumptious continental or American breakfast to fuel your adventures. If you need to stay plugged in for work, there's a business center on site, along with vending machines stocked with snacks to satisfy your cravings. With its heartwarming atmosphere and thoughtful amenities, the Holiday Inn St Louis SW - Route 66 is a wonderful spot to unwind and dive into the delightful experiences that await you in St. Louis!

Dan Avramescu's profile

Dan Avramescu

Dan, a digital nomad with 10+ years of experience, has traveled to 55+ countries, sharing expert tips to help others find the best places to stay.

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Post was updated on May 20, 2025

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