If you’re planning a trip to San Diego and looking for a cozy place to stay near Santa Fe Depot, you’re in the right spot! I’ve explored the area and discovered some fantastic hotels that offer comfort, great amenities, and easy access to local attractions. Whether you're traveling solo, with family, or on a romantic getaway, there's something on this list for everyone. Let’s dive in and find the perfect home base for your San Diego adventure!
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Distance to the Santa Fe Depot: 0.1 mi (0.2km)
The Residence Inn by Marriott San Diego Downtown/Bayfront is a fantastic option! This cozy hotel offers free bikes for exploring the area, plus an outdoor swimming pool to take a refreshing dip. Guests can enjoy a delightful meal at the on-site restaurant, and there’s a comfy shared lounge to relax in whenever you like. Need to stay connected? You’ll find free WiFi throughout the place, and if you want to whip up some snacks, certain rooms come equipped with kitchens featuring a fridge, microwave, and dishwasher.
Start your day with a delicious American breakfast before diving into city adventures. Whether you're hitting the business center for work or unwinding with a drink at the bar after a busy day, this hotel has you covered. Plus, amazing spots like the Maritime Museum of San Diego and the USS Midway Museum are just a quick stroll away, putting you right in the heart of the action!
Distance to the Santa Fe Depot: 0.1 mi (0.2km)
Looking for the perfect spot to stay near Santa Fe Depot in San Diego? Look no further than the InterContinental San Diego! This charming boutique hotel sits right on the waterfront and features spectacular views of the San Diego Bay, thanks to its floor-to-ceiling windows. With three dining options and a rooftop bar on the 4th floor, there's plenty of delicious food and drinks to enjoy. Imagine savoring a meal at Vistal, where flavors inspired by the Baja Peninsula and the Pacific Islands come together in mouthwatering dishes.
You’ll feel right at home in cozy guest rooms equipped with air conditioning, a 49-inch TV, and even a coffee machine for your morning brew. Slip into a comfy bathrobe and kick back after a day of exploring. Need to get your sweat on? The expansive health center offers fantastic views and an outdoor yoga terrace, perfect for unwinding. Plus, top attractions like the USS Midway Museum and PETCO Park are just a short drive away, so excitement is never far from your doorstep!
Distance to the Santa Fe Depot: 0.1 mi (0.2km)
If you’re on the hunt for a fantastic place to stay near Santa Fe Depot in San Diego, The Guild Hotel is a delightful pick! Just a hop away from city center attractions, this Marriott Tribute Portfolio hotel has everything you need for a fun and relaxing stay. Enjoy complimentary bikes to explore the area, savor tasty food at the on-site restaurant, or unwind in the cozy garden. Plus, with free WiFi and 24-hour front desk service, your comfort and convenience are guaranteed!
Rooms at The Guild Hotel are designed with your comfort in mind, featuring cozy kitchens in some units, perfect for whipping up your favorite snacks. Start your day off right with an American, vegetarian, or vegan breakfast that caters to every palate. Don't forget to take advantage of the sunny terrace, where you can soak up the beautiful San Diego weather or get adventurous with hiking and cycling nearby. With so much to enjoy, you might just find yourself wanting to stay a little longer!
Distance to the Santa Fe Depot: 0.1 mi (0.2km)
If you're looking for a great spot near Santa Fe Depot in sunny San Diego, check out the SpringHill Suites by Marriott San Diego Downtown/Bayfront! This hotel features a sparkling outdoor pool and a gym where you can keep up with your fitness routine. Complimentary WiFi is available throughout the hotel, so you can easily share your San Diego adventures with friends and family.
You can choose from cozy rooms equipped with flat-screen TVs and comfy private bathrooms. Some even offer fantastic views of the ocean or the city! The friendly front desk team is available 24/7 if you need any help or recommendations during your stay. Whether you’re visiting for business or just a relaxing getaway, SpringHill Suites offers a friendly atmosphere and all the amenities you need for a delightful stay!
If you’re on the hunt for a fantastic hotel near Santa Fe Depot in San Diego, The Westin San Diego Bayview could be just what you need. This stylish, downtown gem has recently been revamped and is just a pleasant stroll away from Seaport Village and the San Diego Convention Center. With a relaxed on-site restaurant and a cozy café serving delicious coffee and baked goods, you’ll find plenty of tasty options to enjoy during your stay!
When it comes to relaxation, The Westin has you covered. Take a dip in the outdoor pool or unwind in the hot tub after a workout in the well-equipped gym. You can refresh in spacious rooms that come with all the essentials, like an HDTV, complimentary water, and even Starbucks coffee! There’s something special about making your morning feel just a little bit brighter. Plus, with attractions like the San Diego Zoo and the Maritime Museum nearby, adventure is always within reach.
Distance to the Santa Fe Depot: 0.2 mi (0.3km)
If you're searching for the perfect place to stay near Santa Fe Depot in San Diego, look no further than Hotel Republic San Diego! This trendy spot boasts a cool lounge, a delicious restaurant, and a contemporary art gallery that brings a creative vibe to your getaway. With cozy guest rooms fitted with flat-screen HDTVs, oversized desks, and great in-room dining options, you’ll feel right at home. Plus, our eco-friendly environment welcomes your furry companions, so your pets are part of the fun too!
Dining is a treat here! Enjoy mouthwatering California cuisine at one of the two on-site restaurants. Don’t miss out on a nightcap at the Topside Terrace Kitchen & Bar, where you can sip drinks and snuggle around a sculpture of stacked beach chairs—all while soaking in stunning city views. With a 24-hour fitness center available, keeping up with your workout routine has never been easier. Friendly staff members can also help arrange transportation, book event tickets, and make dinner reservations, ensuring a fantastic stay from start to finish!
If you’re looking for a great place to stay near Santa Fe Depot in San Diego, Best Western Plus Bayside Inn is a fantastic choice! This welcoming hotel features a heated outdoor pool and a relaxing hot tub, perfect for unwinding after a busy day exploring the city. Plus, you can stay connected with free WiFi throughout your stay.
Each cozy guest room offers balconies with beautiful views of the San Diego skyline, a cable TV for your entertainment, and handy amenities like microwaves and refrigerators. Start your day right with a complimentary grab-and-go breakfast before hitting the city. With just a short stroll to the vibrant Gaslamp Quarter and the delicious dining scene in Little Italy, you’ve got so much to explore nearby. Whether you’re traveling on business or for a fun getaway, you're sure to enjoy the friendly atmosphere and comfort at Best Western Plus Bayside Inn!
If you’re searching for a fantastic spot to stay close to Santa Fe Depot in San Diego, the Wyndham San Diego Bayside is a great pick! This charming hotel offers three delightful on-site restaurants, so you can enjoy a hearty meal without even stepping out. Dive into some delicious gourmet steaks at Ruth's Chris Steak House or grab a quick bite with a lovely view at Hazelwood's Bayside Deli. Plus, a free shuttle service makes it easy to get around, letting you breeze through your plans.
All guest rooms come with free WiFi and cable TV, ensuring you have everything you need for a comfy stay. Some rooms even have furnished balconies with stunning views of the bay! Get ready to relax by the outdoor pool or break a sweat in the poolside gym. If you're feeling adventurous, they also offer bike rentals, making it a breeze to explore the beautiful surroundings. You'll be just a short hop away from attractions like the San Diego Convention Center and the lively Gaslamp Quarter. Enjoy your stay!
Distance to the Santa Fe Depot: 0.2 mi (0.4km)
If you’re on the hunt for a cozy place to stay near Santa Fe Depot in San Diego, the Carte Hotel is a great choice! This sleek hotel has everything you need, including a refreshing outdoor pool, a fitness center for your workouts, and a welcoming lounge area to unwind. You can treat yourself to delicious meals at the on-site restaurant and sip on tasty drinks at the bar. Plus, a sauna and hot tub are perfect for a little luxury at the end of the day.
Your room at Carte Hotel comes packed with amenities to make your stay super comfy. You’ll have air conditioning, a coffee machine for your morning brew, a fridge to keep your snacks handy, a flat-screen TV for evening entertainment, and a private bathroom stocked with essentials. They even offer a great breakfast each morning, whether you’re in the mood for a hearty American meal or some vegetarian options.
Conveniently located, you can easily explore nearby attractions like the Maritime Museum of San Diego and the USS Midway Museum. Enjoy your getaway in this lively city!
Just a hop away from Santa Fe Depot, the Sofia Hotel is a fantastic spot to kick back and recharge during your San Diego adventure. Nestled near the Gaslamp Quarter, this charming hotel offers a delightful mix of modern amenities and cozy comfort. With a top-notch restaurant and spa services right on site, you’ll find everything you need to relax after a fun day exploring the city.
Each guestroom is designed with your comfort in mind, featuring iPod docking stations, flat-screen TVs, and all the essentials like coffee machines, a fridge, and even a microwave. Plus, you can indulge in some in-room spa treatments whenever the mood strikes! When hunger hits, don't miss out on yummy meals and a vibrant happy hour at the Currant American Brasserie.
Whether you’re rolling right into the city for a weekend getaway or just need a lovable home base for your adventures, the Sofia Hotel has your back. It’s a wonderful place to create special memories in sunny San Diego!
The Hampton Inn San Diego Downtown is a great choice for anyone looking to enjoy all that San Diego has to offer. Just a short stroll from attractions like the San Diego Convention Center, the historic Gaslamp Quarter, and the bustlingLittle Italy district, you’ll find plenty to explore nearby. It's the perfect spot to immerse yourself in the vibrant culture of the city!
Start your day with a yummy free continental breakfast before heading out to sightsee. After a day full of adventures, kick back at the rooftop pool and take in fantastic views of the bay, or squeeze in a workout at the fully-equipped fitness center. Whether you're here for fun or business, the Hampton Inn is a cozy retreat that will help you recharge for your next outing!
The Bristol Hotel is a charming boutique oasis right in the heart of Downtown San Diego. You'll love the fresh, modern vibe after the recent renovations. Each cozy guest room is equipped with an LCD TV, a fridge, and a coffee maker, offering just what you need to unwind or start your day right. Plus, it’s all non-smoking, which adds to the relaxing atmosphere!
This hotel is all about making your stay special, with eco-friendly bath amenities to keep things green and clean. Convenient valet parking is available, so you can explore San Diego at your leisure. Whether you're catching a show at the San Diego Civic Theatre or enjoying a leisurely walk to the nearby Convention Center, The Bristol places you right in the mix of all the fun dining, shopping, and activities in beautiful San Diego!
Distance to the Santa Fe Depot: 0.4 mi (0.6km)
Embassy Suites by Hilton San Diego Bay Downtown is a fantastic choice for anyone looking to enjoy the best of downtown San Diego. With an awesome indoor pool and a fitness center, it's a great spot to unwind after exploring the city. Start your day off right with a complimentary cooked-to-order breakfast that'll get you fueled for adventures! In just a short walk, you can visit the USS Midway Museum and dive into some maritime history.
The spacious air-conditioned suites are designed with your comfort in mind. You'll find a cozy living area complete with a sofa bed, a well-lit workspace, and handy amenities like a microwave and refrigerator. Gather with friends during the complimentary Evening Reception for chilled drinks and a chance to mingle from 5:30 to 7:30 PM. Need to keep connected? The business center is ready to help with any tasks while 24/7 reception staff ensures you have everything you need.
If you’re on the hunt for a charming place to stay near Santa Fe Depot in San Diego, check out Quaint Little Italy Suites by Sonder. Just a short walk from some cool attractions, this spot has cozy accommodations that feel like home. You’ll love having your very own kitchen, complete with an oven, microwave, coffee machine, toaster, and kettle—everything you need to whip up a quick breakfast or a midnight snack. Plus, enjoy free WiFi to keep you connected, whether you’re sharing travel pics or planning your next adventure.
Each suite comes with a lovely dining area and a terrace to soak in the sunshine or enjoy a cup of coffee. It’s the perfect spot to relax after exploring the vibrant Little Italy neighborhood, with its many restaurants and artsy spots. This charming hotel is ready to make your stay special and comfortable. Why not book your stay and experience it for yourself?
Looking for a cozy place to stay near Santa Fe Depot in San Diego? You can’t go wrong with Urban Boutique Hotel! Set in the heart of Little Italy, this charming hotel offers free Wi-Fi and comfortable rooms that feel like home. Each room is equipped with air conditioning, a cable TV, a coffee maker, and a handy laptop safe. You’ll also find private bathrooms featuring fresh towels, plus a warm and welcoming 24-hour reception ready to help you whenever you need.
After a day of exploring the nearby sights, such as fantastic dining and vibrant artsy spots, come back and unwind in your relaxing room. Urban Boutique Hotel perfectly blends convenience and comfort, making it an ideal choice for your San Diego adventure. Book your stay today for a delightful experience!
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Dan, a digital nomad with 10+ years of experience, has traveled to 55+ countries, sharing expert tips to help others find the best places to stay.
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Post was updated on April 20, 2025
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