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15 Top Hotels in Mission District San Francisco

When I first visited the Mission District in San Francisco, I was captivated by its vibrant culture and colorful murals. Finding the perfect place to stay makes all the difference in experiencing this lively neighborhood. In this article, I've rounded up 15 top hotels in the Mission District, each offering unique comforts and a chance to immerse yourself in local life. Whether you're looking for budget-friendly options or a little luxury, you’ll find just the right spot to unwind after exploring this eclectic area. Let’s dive into some great accommodations that will make your stay unforgettable!

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Parker Guest House ImageParker Guest House ImageParker Guest House Image
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Parker Guest House

Distance to the Mission District San Francisco: 0.6 mi (1km)

9.3/10

Parker Guest House is a charming spot in the heart of San Francisco, perfect for your next getaway. This cozy hotel features a lovely garden and offers a concierge service to help make your stay even sweeter. Parking is available but needs to be reserved ahead of time. Guests can also enjoy the convenience of a computer and printer right on-site.

The rooms are designed for comfort with free WiFi, a private bathroom, and a ROKU flat-screen TV with cable channels. Each morning, you can start your day with a tasty continental or buffet breakfast, and afterward, you might want to relax on the sunny terrace. With plenty to see and do nearby, you’re sure to enjoy your stay at Parker Guest House!

Hayes Valley Inn ImageHayes Valley Inn ImageHayes Valley Inn Image
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Hayes Valley Inn

Distance to the Mission District San Francisco: 1 mi (1.6km)

7.3/10

Hayes Valley Inn is a delightful place to stay in the lively Hayes Valley neighborhood of San Francisco. Just a stroll away from the enchanting San Francisco War Memorial Opera House and iconic City Hall, it's easy to take in the sights right from your doorstep. The inn features cozy rooms equipped with free WiFi and shared bathrooms, making it an inviting choice for budget travelers who don't mind sharing facilities.

When it comes to exploring the area, you’re in for a treat! Hayes Valley is packed with charming boutiques, fascinating art galleries, and cozy cafes, perfect for a leisurely outing. You can check out the Asian Art Museum and catch a concert at the Bill Graham Civic Auditorium, both just a short drive away. This friendly inn sets the stage for making awesome memories during your San Francisco adventure!

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Inn On Grove

Distance to the Mission District San Francisco: 1 mi (1.6km)

7.8/10

Inn On Grove is a charming spot in San Francisco that brings a cozy touch to your stay! With its welcoming vibe, this 3-star hotel offers comfortable rooms fitted with free WiFi, so you can stay connected while you explore the city. Each room also comes with a private bathroom and essential goodies like bed linens and towels, ensuring you feel at home during your visit. Plus, the friendly 24-hour front desk is always ready to help with anything you might need.

Located in the lively Western Addition neighborhood, you’ll find yourself just a heartbeat away from the city’s best attractions. Take a short trip to bustling sites like the vibrant city hall, or get lost in the charm of nearby local parks and shops. Whether you're in town for adventure or relaxation, Inn On Grove is the perfect base for creating unforgettable memories in San Francisco!

The Hotel Castro San Francisco ImageThe Hotel Castro San Francisco ImageThe Hotel Castro San Francisco Image
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The Hotel Castro San Francisco

Distance to the Mission District San Francisco: 1.1 mi (1.7km)

8.3/10

The Hotel Castro San Francisco is a delightful spot located in the heart of the city, where comfort meets convenience! Each air-conditioned room comes perfectly equipped with everything you need, like a private bathroom and a fridge. You’ll also find a flat-screen TV to enjoy during your downtime, along with cozy bed linens and towels. Plus, with free WiFi, you can easily share your favorite San Francisco moments with friends and family!

This non-smoking hotel puts you close to some fantastic San Francisco destinations. Explore vibrant spots like Oracle Park, Moscone Center, or take a scenic stroll to the picturesque Ghirardelli Square. Whether you're here for a fun adventure or a relaxing getaway, The Hotel Castro makes a great home base to create lasting memories in this iconic city.

Casa Loma Hotel ImageCasa Loma Hotel ImageCasa Loma Hotel Image
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Casa Loma Hotel

Distance to the Mission District San Francisco: 1.1 mi (1.7km)

7.3/10

Welcome to Casa Loma Hotel, a charming retreat in the heart of San Francisco! Step into a cozy atmosphere that embraces you like an old friend, blending European elegance with the vibrant vibes of the city. Each room comes equipped with free Wi-Fi and plenty of space to settle in, whether you choose a private bathroom or share. The 24-hour reception team is always ready to help with anything you need, making sure your stay is super comfy.

Located just a stone’s throw from famous spots like Golden Gate Park and the California Academy of Sciences, there’s always something exciting to explore. While some minor construction is ongoing to make the Casa Loma even better, our friendly staff is here 24/7 to keep your experience seamless and enjoyable. We truly appreciate your understanding and we can’t wait to welcome you soon!

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Hotel Fiona

Distance to the Mission District San Francisco: 1.1 mi (1.8km)

7.9/10

Hotel Fiona is a delightful spot in San Francisco’s SoMa district, packed with museums, shops, and fantastic eateries. With a family-friendly vibe and a touch of Victorian charm, it’s a perfect pick for travelers. Kick off each day with complimentary coffee and tea in the lobby, and enjoy a splash in the heated outdoor pool or a workout at the nearby sister property. To top it off, every room pays homage to San Francisco’s legends, complete with smart TVs, free Wi-Fi, cozy robes, and coffee machines to keep you feeling right at home.

Exploring the city is a breeze from Hotel Fiona! Just a quick stroll gets you to The Strand Theater, and sports fans can cheer on the Giants at AT&T Park nearby. If you’re driving, there's on-site parking available, so all you have to think about is making the most of your trip. With all this and more, Hotel Fiona makes for an excellent base to dive into the heart of San Francisco’s exciting offerings!

Yotel San Francisco ImageYotel San Francisco ImageYotel San Francisco Image
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Yotel San Francisco

Distance to the Mission District San Francisco: 1.2 mi (1.9km)

7.5/10

YOTEL San Francisco is a great choice in the heart of the Mission District, offering cool rooms and a convenient in-house restaurant. You can stay connected with free Wi-Fi while kicking back in your cozy room. Some rooms even have a seating area perfect for unwinding after a day of exploring the city’s art and culture. The friendly staff is always eager to help you at the 24-hour front desk, making your stay extra comfortable and easy.

When you stay at YOTEL, you’re just a hop away from exciting attractions like San Francisco City Hall, the Asian Art Museum, and the buzzing Civic Auditorium. Union Square is super close, and you can catch live performances at venues like The Warfield or the SHN Golden Gate Theatre just a few minutes down the road. Whether you’re on a fun getaway or a business trip, YOTEL San Francisco has everything you need for a fabulous stay!

San Francisco Proper Hotel, a Member of Design Hotels ImageSan Francisco Proper Hotel, a Member of Design Hotels ImageSan Francisco Proper Hotel, a Member of Design Hotels Image
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San Francisco Proper Hotel, A Member Of Design Hotels

Distance to the Mission District San Francisco: 1.2 mi (1.9km)

8/10

Step into the charm of San Francisco Proper Hotel, located in a stunning historic flatiron building on Market Street! This isn't just any hotel; it's a unique urban getaway designed for a memorable stay. With free Wi-Fi and soundproof rooms, you can relax in style and access all the hotel's services right from the Proper App. The Civic Center BART Station is just steps away, allowing you to explore the vibrant city with ease.

The guest rooms are packed with goodies like a 50-inch HDTV, comfy boutique linens, and cozy cotton kimono robes. Each room is equipped with double-layered shades to keep it dark and quiet, plus a safe for your laptop. Enjoy tunes with a Bluetooth speaker, sip on drinks from a locally curated minibar, and treat yourself to a luxurious walk-in rain shower. If you're in the mood to dine in, the in-room dining team is on standby to deliver delicious, fresh meals crafted by Chef Mikey Adams.

You're also in luck when it comes to fun happenings nearby! Just a short stroll away, you’ll find the Warfield concert venue and the SHN Golden Gate Theatre, where live performances are just waiting for you. Take a quick walk to the Westfield San Francisco Centre for some shopping and exploration. Whether you're here for a weekend escape or a longer adventure, this hotel has everything to make your stay cozy and delightful!

The Metro Hotel ImageThe Metro Hotel ImageThe Metro Hotel Image
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The Metro Hotel

Distance to the Mission District San Francisco: 1.2 mi (2km)

8.2/10

Nestled in the lively Mission District, The Metro Hotel is a superb choice for those exploring the heart of San Francisco. Offering a cozy 3-star experience, this hotel features a serene garden where you can unwind after a busy day of adventuring. Their welcoming family rooms make it perfect for visitors traveling with loved ones. Plus, the friendly staff is always ready to help, speaking English, Spanish, and French to ensure everyone feels at home.

Each guest room is packed with modern goodies, like a flat-screen TV and free Wi-Fi, helping you stay connected while you relax. Enjoy aprivate bathroom equipped with a shower and fresh hairdryer after a day of city exploration. For those who love a view, some rooms even open up to the lovely garden outside. If you're heading out to see the sights, lots of popular attractions are a short distance away, making it easy to dive into the San Francisco vibe and find something fun to do!

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Phoenix Hotel

Distance to the Mission District San Francisco: 1.3 mi (2.1km)

8.1/10

The Phoenix Hotel offers a fun and quirky stay in San Francisco’s Tenderloin District. This rock 'n' roll haven comes with a refreshing outdoor pool, handy on-site parking, and complimentary Wi-Fi in all rooms. Perfect for music lovers and city explorers, this hotel mixes cool vibes with comfort.

Each room boasts a 42-inch flat-screen TV with DirecTV, plus ironing facilities and a hair dryer for your convenience. Grab a delicious meal or a drink at Chambers eat + drink restaurant, where you can enjoy the inviting poolside patio. You'll also find original art and sculptures sprinkled throughout the courtyard, giving the hotel a creative, inspiring flair. Just a short stroll away, the lively Great American Music Hall awaits, along with the legendary Fillmore music venue just a quick drive away.

Hampton Inn San Francisco Downtown/Convention Center ImageHampton Inn San Francisco Downtown/Convention Center ImageHampton Inn San Francisco Downtown/Convention Center Image
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Hampton Inn San Francisco Downtown/Convention Center

Distance to the Mission District San Francisco: 1.4 mi (2.2km)

7.7/10

Hampton Inn San Francisco Downtown/Convention Center is a cozy spot perfect for visitors wanting to experience the energy of San Francisco. With comfy rooms equipped with free WiFi, a cable TV, and a nice seating area, you'll feel right at home. The hotel's private bathrooms come with showers or baths, making it easy to relax after a day of exploring.

Start your mornings with a tasty free breakfast to fuel your adventures! The friendly staff welcomes you 24/7, ready to help with anything you might need, including luggage storage. Plus, you’re just moments away from the sights and sounds of the city, ensuring you can dive into all the fun San Francisco has to offer.

Timbri Hotel San Francisco, Curio Collection by Hilton ImageTimbri Hotel San Francisco, Curio Collection by Hilton ImageTimbri Hotel San Francisco, Curio Collection by Hilton Image
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Timbri Hotel San Francisco, Curio Collection By Hilton

Distance to the Mission District San Francisco: 1.4 mi (2.3km)

8.1/10

Timbri Hotel San Francisco, Curio Collection by Hilton is a wonderful choice for anyone wanting to soak in the vibrant atmosphere of the city. This boutique hotel features cozy, air-conditioned rooms that promise a comfortable stay. Enjoy complimentary bikes for exploring, free WiFi to keep you connected, and a fitness center to stay active during your trip. With room service and a 24-hour front desk, all your needs are right at your fingertips, and there’s private parking if you have a car.

When it comes to dining, start your day with a delicious American breakfast. The hotel’s restaurant serves up a delightful mix of American and Asian dishes that are sure to please your taste buds. Whether you're here for business or leisure, Timbri is set up to help you make the most of your stay with a business center available and an ATM on-site for convenience. You're in a prime spot to explore some of San Francisco's popular attractions like City Hall and Union Square, making it easy to dive into the local scene!

InterContinental San Francisco, an IHG Hotel ImageInterContinental San Francisco, an IHG Hotel ImageInterContinental San Francisco, an IHG Hotel Image
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InterContinental San Francisco, An IHG Hotel

Distance to the Mission District San Francisco: 1.5 mi (2.3km)

8.6/10

For a fantastic stay in the heart of San Francisco, InterContinental San Francisco offers a fresh, modern vibe a quick stroll from everything the city has to offer. With spacious rooms fitted with the latest tech like flat-screen TVs and iPod docks, your comfort is a priority. Plus, you'll find beverages ready in your in-room minibar and coffee machine, ensuring you're fueled up for your adventures!

Take a dip in the indoor lap pool or work out anytime at the 24-hour fitness center without missing a beat. Treat yourself at Luce restaurant or unwind with a drink at Bar 888. Being a totally smoke-free hotel, InterContinental is also perfectly situated and connects you to both the Moscone Convention Center and the charm of Chinatown, making it an ideal pick for anyone looking to enjoy the best of San Francisco!

The Pickwick Hotel San Francisco ImageThe Pickwick Hotel San Francisco ImageThe Pickwick Hotel San Francisco Image
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The Pickwick Hotel San Francisco

Distance to the Mission District San Francisco: 1.5 mi (2.4km)

7.5/10

The Pickwick Hotel San Francisco is a cozy spot right in the heart of the city, just a short walk from great shopping at the Westfield Centre. With a delightful restaurant and bar on-site, guests can savor some delicious Italian and Mediterranean dishes at SOMA Bar & Restaurant or grab a quick bite at Zevi café. The light and airy guest rooms come equipped with everything you need, including free WiFi, cable TV, a fridge, and a coffee maker to keep you energized during your stay.

For those who like to stay active, The Pickwick offers fitness and business facilities for your convenience. If you’re in the mood to explore, you're also close to famous attractions like the Museum of Modern Art and Fisherman’s Wharf, all just a short drive away. Whether you're in town for business or looking to have some fun, this hotel packs a punch with comfort and convenient amenities!

Hotel Zetta San Francisco ImageHotel Zetta San Francisco ImageHotel Zetta San Francisco Image
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Hotel Zetta San Francisco

Distance to the Mission District San Francisco: 1.5 mi (2.4km)

8/10

In the vibrant Mission District of San Francisco, Hotel Zetta welcomes you with a blend of style and comfort, perfect for your city adventure. Just a hop away from striking shops and attractions, this hotel boasts rooms featuring a 46-inch smart TV, free WiFi, and an Illy espresso machine to kickstart your mornings. Enjoy some relaxation in your cozy seating area or crisp walk-in shower, and embrace some peace and quiet with double-paned windows that keep the hustle-bustle at bay.

Dining is a delight here too! Stop by The Cavalier, the on-site UK-style brasserie, for some mouthwatering meals, or unwind at the bar and lounge after a day of exploring. Stay fit in the modern fitness center, try out the games room, or get some help from the friendly concierge. This hotel provides everything you need for a fantastic San Francisco getaway!

Dan Avramescu's profile

Dan Avramescu

Dan, a digital nomad with 10+ years of experience, has traveled to 55+ countries, sharing expert tips to help others find the best places to stay.

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Post was updated on April 4, 2025

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