Jacksonville surprises visitors with its vibrant San Marco neighborhood and incredible hotel options. I've curated a list of seven standout hotels that will elevate your stay in this dynamic Florida city. From boutique gems to comfortable retreats, these properties offer something special for every traveler looking to explore Jacksonville's charm and hospitality.
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1201 Kings Avenue | 0.3 mi (0.5km) to San Marco
Nestled in downtown Jacksonville, this Homewood Suites offers spacious, well-appointed rooms with flat-screen TVs, a fitness center, and an inviting outdoor pool perfect for relaxation. Guests enjoy a complimentary buffet breakfast and convenient access to local attractions like the Museum of Science & History and Theatre Jacksonville.
1201 Kings Avenue | 0.3 mi (0.6km) to San Marco
Situated in downtown Jacksonville's vibrant Southbank district, this Hilton Garden Inn offers modern, well-equipped rooms with flat-screen TVs and HBO, plus convenient amenities like an outdoor pool, hot tub, and 24-hour fitness center. Guests enjoy easy access to EverBank Field, Jacksonville Zoo, and Times Union Center, making this hotel an ideal base for exploring the city's top attractions.
1515 Prudential Drive | 0.7 mi (1.1km) to San Marco
Situated along the St. Johns River in San Marco, Southbank Hotel offers modern rooms with river-view balconies, a fitness center, and Pier 1515 restaurant serving casual American cuisine. Steps from local museums and entertainment, this waterfront hotel provides convenient amenities like a 24-hour business center and Currents Lounge for relaxing evening drinks.
225 East Coastline Drive | 1.1 mi (1.8km) to San Marco
Overlooking the St. Johns River, this Hyatt Regency offers a rooftop pool, 24/7 dining at Market, and spacious rooms with river views and modern amenities. Just steps from Jacksonville Landing, the hotel provides a free city shuttle and SHOR Seafood Grill for regional cuisine.
245 Water Street | 1.3 mi (2.2km) to San Marco
Located in downtown Jacksonville, this Marriott hotel offers modern rooms with Keurig® coffee machines and flat-screen TVs, steps away from the Times-Union Center for the Performing Arts. Guests enjoy complimentary amenities including a 24-hour fitness center, on-site Juliette's Bistro serving contemporary American cuisine, and convenient access to Jacksonville Landing's vibrant shopping and entertainment district.
357 Oak Street | 1.7 mi (2.7km) to San Marco
This downtown Residence Inn offers spacious studio-style suites with full kitchens, a fitness center, and an outdoor pool perfect for business and leisure travelers. Conveniently located near Jacksonville's key attractions like the Florida Theatre and Cummer Museum, the hotel provides comfortable, well-equipped accommodations with complimentary breakfast and 24-hour business services.
600 Park Street | 1.7 mi (2.8km) to San Marco
Modern Downtown Jacksonville hotel with spacious suites, complimentary parking, and a 24-hour fitness center just steps from the city's cultural attractions. Home2 Suites offers comfortable rooms with air conditioning, flat-screen TVs, and work desks, plus a daily buffet breakfast to start the day right.
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Olga, a hospitality graduate with 10+ years of experience in hotels and travel blogging, has explored Europe extensively and shares expert travel insights.
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Post was updated on July 14, 2025
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