Jacksonville blends history, science, and fun, making it a perfect destination for curious travelers! Right next to the incredible Museum of Science and History (MOSH), these hotels offer the perfect home base for exploring this vibrant Florida city. We've carefully curated a list that ensures you'll find comfortable, convenient accommodations just steps away from one of Jacksonville's most fascinating attractions. Whether you're a solo traveler, family explorer, or business visitor, these hotels promise a memorable stay in the heart of Northeast Florida's coolest museum district.
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1515 Prudential Drive | 0.4 mi (0.6km) to MOSH
Situated along the St. Johns River in Jacksonville's vibrant San Marco district, Southbank Hotel offers contemporary rooms with river-view balconies, a fitness center, and Pier 1515 restaurant serving casual American cuisine. Just steps from the Museum of Science and History, the hotel provides convenient access to downtown attractions, a 24-hour business center, and a relaxing outdoor pool with a sundeck.
225 East Coastline Drive | 0.4 mi (0.7km) to MOSH
Situated along the St. Johns River, this sleek Hyatt Regency offers stunning waterfront views, a rooftop pool, and three diverse dining options including SHOR Seafood Grill. The hotel provides modern amenities like free WiFi, a 24-hour fitness center, and a convenient city shuttle, making it an ideal base for exploring Jacksonville's vibrant downtown.
245 Water Street | 0.5 mi (0.8km) to MOSH
Located in downtown Jacksonville, this Marriott hotel offers modern rooms with Keurig® coffee machines, a 24-hour fitness center, and Juliette's Bistro serving American cuisine. Just steps from Jacksonville Landing and the Museum of Science and History, the property provides convenient access to local attractions with free WiFi and a welcoming concierge service.
1201 Kings Avenue | 0.6 mi (0.9km) to MOSH
Situated in downtown Jacksonville's vibrant Southbank district, this Hilton Garden Inn offers modern, well-appointed rooms with HBO-equipped flat-screen TVs and convenient amenities like an iPod docking station. The hotel provides guests with an on-site fitness center, business facilities, and an inviting outdoor pool with hot tub, making it an ideal choice for both leisure and business travelers exploring Jacksonville's attractions like MOSH and EverBank Field.
1201 Kings Avenue | 0.6 mi (0.9km) to MOSH
Centrally located in Downtown Jacksonville, this Homewood Suites offers spacious, modern rooms with flat-screen TVs, a fitness center, and an inviting outdoor pool perfect for relaxing after exploring nearby attractions. The hotel provides a complimentary buffet breakfast and convenient amenities like free WiFi and private parking, making it an ideal home base for museum and downtown adventures.
357 Oak Street | 1 mi (1.6km) to MOSH
Residence Inn by Marriott Jacksonville Downtown offers spacious studio-style suites with full kitchens, a complimentary buffet breakfast, and an outdoor pool perfect for relaxing near downtown attractions. Located steps from the Prime F. Osborn III Convention Center, this property provides convenient access to Jacksonville's cultural sites with modern amenities and comfortable, apartment-like accommodations.
600 Park Street | 1.1 mi (1.8km) to MOSH
Home2 Suites By Hilton offers modern comfort in downtown Jacksonville, with spacious rooms featuring air conditioning, flat-screen TVs, and work desks. Guests enjoy complimentary breakfast, free parking, a fitness center, and convenient proximity to the Museum of Science and History and Florida Theatre.
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Olga, a hospitality graduate with 10+ years of experience in hotels and travel blogging, has explored Europe extensively and shares expert travel insights.
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Post was updated on July 22, 2025
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