Planning a trip to Jacksonville for medical care or visiting Mayo Clinic? I've curated a list of top hotels that make your stay comfortable, convenient, and stress-free. These carefully selected accommodations are located just minutes from the clinic, offering easy access and peace of mind during your medical journey. Whether you need a budget-friendly room or a luxurious suite, I'll help you find the perfect place to rest and recharge while taking care of your health.
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14390 Mayo Boulevard | 0.2 mi (0.4km) to Mayo Clinic
Courtyard by Marriott offers convenient comfort near Mayo Clinic with modern rooms, free clinic transfers, and an on-site bistro serving breakfast and dinner. Guests enjoy amenities like a fitness center, 24-hour market, free WiFi, and easy access to Jacksonville Beach and local attractions.
4905 San Pablo Road South | 0.7 mi (1.1km) to Mayo Clinic
Residence Inn offers comfortable extended-stay suites with fully equipped kitchens, perfect for Mayo Clinic patients and families seeking a home-like environment. Located near the medical center, the hotel provides convenient amenities including free bikes, an outdoor pool, fitness center, and complimentary WiFi to ensure a comfortable and stress-free stay.
4791 Windsor Commons Court | 1.6 mi (2.6km) to Mayo Clinic
Conveniently located near Mayo Clinic, this Holiday Inn Express offers modern rooms with 32-inch flat-screen TVs, microwaves, and free WiFi, complemented by an Express Start Breakfast Bar and weekday shuttle service. Guests can enjoy the fitness center, free parking, and close proximity to Jacksonville Beach and Windsor Parke Golf Club.
13733 Beach Boulevard | 1.9 mi (3.1km) to Mayo Clinic
Just steps from Mayo Clinic, this Hampton Inn offers comfortable rooms with free Wi-Fi, a hot breakfast, and convenient amenities like an indoor pool and fitness center. Conveniently located near Jacksonville Beach and local attractions, the hotel provides a perfect blend of comfort and accessibility for business and leisure travelers.
13741 Beach Boulevard | 1.9 mi (3.1km) to Mayo Clinic
TownePlace Suites offers spacious, non-smoking rooms with free WiFi and a buffet breakfast, perfect for business travelers and visitors to Mayo Clinic. With an outdoor swimming pool, garden, and convenient business center, this 3-star hotel provides comfortable accommodations near Jacksonville Beach Golf Club and local attractions.
1101 Beach Boulevard | 2.9 mi (4.7km) to Mayo Clinic
Holiday Inn Express Jacksonville Beach offers modern, well-equipped rooms with free Wi-Fi, a microwave, and refrigerator, just steps from beautiful Atlantic Ocean beaches. Guests enjoy a complimentary hot breakfast featuring eggs and breakfast meats, plus free access to an on-site fitness room, making this an ideal stay near Adventure Landing Amusement Park and Jacksonville Beach Golf Club.
208 Beach Boulevard | 3.4 mi (5.5km) to Mayo Clinic
Element Jacksonville Beach offers contemporary accommodations with free bikes, a fitness center, and kitchen-equipped rooms just steps from the beach. Guests enjoy a 24-hour front desk, complimentary WiFi, and a spacious terrace perfect for relaxing after exploring Neptune Beach and local attractions.
11 First Street North | 3.5 mi (5.7km) to Mayo Clinic
Four Points by Sheraton Jacksonville Beachfront offers spacious oceanfront suites with private balconies, a fitness center, and direct beach access along Highway A1A. With an on-site restaurant serving hot breakfast, a convenient shuttle service, and modern amenities like free WiFi and flat-screen TVs, this beachside hotel provides a comfortable and convenient stay near Jacksonville's attractions.
305 1st Street North | 3.6 mi (5.8km) to Mayo Clinic
Located steps from the Atlantic Ocean, this Best Western Oceanfront offers comfortable rooms with microwaves, refrigerators, and electronic safe boxes. Guests enjoy a free hot breakfast, complimentary WiFi, and convenient access to local golfing and Jacksonville attractions.
465 North First Street | 3.6 mi (5.8km) to Mayo Clinic
SpringHill Suites by Marriott offers a beachfront oasis with direct ocean access, featuring a sun-drenched terrace, outdoor pool, and modern fitness center just steps from Neptune Beach. Guests enjoy complimentary WiFi, an on-site restaurant, and comfortable rooms with contemporary amenities, making this oceanfront property an ideal destination for business and leisure travelers.
1515 First Street North | 4 mi (6.4km) to Mayo Clinic
This beachfront Hampton Inn offers stunning Atlantic Ocean views with a unique outdoor pool featuring four waterfalls and a relaxing hot tub. Guests enjoy convenient amenities like free parking, modern rooms with 55-inch flat-screen TVs, and on-site dining at the Oasis Grill and Tides Oceanfront Tiki Bar.
1616 North First Street | 4 mi (6.4km) to Mayo Clinic
Nestled near Jacksonville Beach, this Fairfield Inn offers comfortable rooms, a refreshing outdoor pool, and a hot tub for relaxing after beach adventures. Guests enjoy free WiFi, a convenient business center, and a hearty American breakfast to start the day right.
1617 North First Street | 4 mi (6.4km) to Mayo Clinic
Situated directly on Jacksonville Beach, this oceanfront Courtyard hotel offers stunning coastal views, a fitness center, and comfortable rooms with balconies and modern amenities like flat-screen TVs and free WiFi. The Bistro serves Starbucks coffee, light appetizers, and evening drinks, providing convenient dining just steps from the beach.
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Olga, a hospitality graduate with 10+ years of experience in hotels and travel blogging, has explored Europe extensively and shares expert travel insights.
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Post was updated on July 9, 2025
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