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13 Top Hotels in Jacksonville near Mayo Clinic

Planning a trip to Jacksonville for medical care or visiting Mayo Clinic? I've curated a list of top hotels that make your stay comfortable, convenient, and stress-free. These carefully selected accommodations are located just minutes from the clinic, offering easy access and peace of mind during your medical journey. Whether you need a budget-friendly room or a luxurious suite, I'll help you find the perfect place to rest and recharge while taking care of your health.

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Residence Inn By Marriott Jacksonville-Mayo Clinic Area

Residence Inn By Marriott Jacksonville-Mayo Clinic Area

Courtyard By Marriott Jacksonville At The Mayo Clinic Campus/Beaches

14390 Mayo Boulevard | 0.2 mi (0.4km) to Mayo Clinic

7.9Good
Courtyard by Marriott Jacksonville at the Mayo Clinic Campus/Beaches ImageCourtyard by Marriott Jacksonville at the Mayo Clinic Campus/Beaches ImageCourtyard by Marriott Jacksonville at the Mayo Clinic Campus/Beaches Image

Courtyard by Marriott offers convenient comfort near Mayo Clinic with modern rooms, free clinic transfers, and an on-site bistro serving breakfast and dinner. Guests enjoy amenities like a fitness center, 24-hour market, free WiFi, and easy access to Jacksonville Beach and local attractions.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Regency Square
Neptune Beach
Windsor Parke Golf Club
Urban Golf

Important Info

Parking available
Free WiFi in rooms
No pets allowed
Family friendly

Residence Inn By Marriott Jacksonville-Mayo Clinic Area

4905 San Pablo Road South | 0.7 mi (1.1km) to Mayo Clinic

9.2Exceptional
Residence Inn By Marriott Jacksonville-Mayo Clinic Area ImageResidence Inn By Marriott Jacksonville-Mayo Clinic Area ImageResidence Inn By Marriott Jacksonville-Mayo Clinic Area Image

Residence Inn offers comfortable extended-stay suites with fully equipped kitchens, perfect for Mayo Clinic patients and families seeking a home-like environment. Located near the medical center, the hotel provides convenient amenities including free bikes, an outdoor pool, fitness center, and complimentary WiFi to ensure a comfortable and stress-free stay.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Regency Square
Neptune Beach
Windsor Parke Golf Club
Marsh Landing Country Club

Important Info

Parking available
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Holiday Inn Express & Suites Jacksonville South East - Medical Center Area, An IHG Hotel

4791 Windsor Commons Court | 1.6 mi (2.6km) to Mayo Clinic

8.1Very Good
Holiday Inn Express & Suites Jacksonville South East - Medical Center Area, an IHG Hotel ImageHoliday Inn Express & Suites Jacksonville South East - Medical Center Area, an IHG Hotel ImageHoliday Inn Express & Suites Jacksonville South East - Medical Center Area, an IHG Hotel Image

Conveniently located near Mayo Clinic, this Holiday Inn Express offers modern rooms with 32-inch flat-screen TVs, microwaves, and free WiFi, complemented by an Express Start Breakfast Bar and weekday shuttle service. Guests can enjoy the fitness center, free parking, and close proximity to Jacksonville Beach and Windsor Parke Golf Club.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Regency Square
Neptune Beach
Windsor Parke Golf Club
Urban Golf

Important Info

Parking available
Free WiFi throughout
No pets allowed
Family friendly

Hampton Inn & Suites Jacksonville Beach Boulevard/Mayo Clinic

13733 Beach Boulevard | 1.9 mi (3.1km) to Mayo Clinic

8.6Excellent
Hampton Inn & Suites Jacksonville Beach Boulevard/Mayo Clinic ImageHampton Inn & Suites Jacksonville Beach Boulevard/Mayo Clinic ImageHampton Inn & Suites Jacksonville Beach Boulevard/Mayo Clinic Image

Just steps from Mayo Clinic, this Hampton Inn offers comfortable rooms with free Wi-Fi, a hot breakfast, and convenient amenities like an indoor pool and fitness center. Conveniently located near Jacksonville Beach and local attractions, the hotel provides a perfect blend of comfort and accessibility for business and leisure travelers.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Regency Square
Neptune Beach
Urban Golf
Windsor Parke Golf Club

Important Info

Parking available
Free WiFi throughout
No pets allowed
Family friendly

TownePlace Suites By Marriott Jacksonville East

13741 Beach Boulevard | 1.9 mi (3.1km) to Mayo Clinic

8.8Excellent
TownePlace Suites by Marriott Jacksonville East ImageTownePlace Suites by Marriott Jacksonville East ImageTownePlace Suites by Marriott Jacksonville East Image

TownePlace Suites offers spacious, non-smoking rooms with free WiFi and a buffet breakfast, perfect for business travelers and visitors to Mayo Clinic. With an outdoor swimming pool, garden, and convenient business center, this 3-star hotel provides comfortable accommodations near Jacksonville Beach Golf Club and local attractions.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Regency Square
Neptune Beach
Urban Golf
Windsor Parke Golf Club

Important Info

Parking available
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Holiday Inn Express Jacksonville Beach, An IHG Hotel

1101 Beach Boulevard | 2.9 mi (4.7km) to Mayo Clinic

8.8Excellent
Holiday Inn Express Jacksonville Beach, an IHG Hotel ImageHoliday Inn Express Jacksonville Beach, an IHG Hotel ImageHoliday Inn Express Jacksonville Beach, an IHG Hotel Image

Holiday Inn Express Jacksonville Beach offers modern, well-equipped rooms with free Wi-Fi, a microwave, and refrigerator, just steps from beautiful Atlantic Ocean beaches. Guests enjoy a complimentary hot breakfast featuring eggs and breakfast meats, plus free access to an on-site fitness room, making this an ideal stay near Adventure Landing Amusement Park and Jacksonville Beach Golf Club.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Gonzales Park
Beaches Museum & History Park

Important Info

Parking available
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Element Jacksonville Beach

208 Beach Boulevard | 3.4 mi (5.5km) to Mayo Clinic

9.4Exceptional
Element Jacksonville Beach ImageElement Jacksonville Beach ImageElement Jacksonville Beach Image

Element Jacksonville Beach offers contemporary accommodations with free bikes, a fitness center, and kitchen-equipped rooms just steps from the beach. Guests enjoy a 24-hour front desk, complimentary WiFi, and a spacious terrace perfect for relaxing after exploring Neptune Beach and local attractions.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Beaches Museum & History Park
Gonzales Park

Important Info

Parking: USD 15/day
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Four Points By Sheraton Jacksonville Beachfront

11 First Street North | 3.5 mi (5.7km) to Mayo Clinic

8.8Excellent
Four Points by Sheraton Jacksonville Beachfront ImageFour Points by Sheraton Jacksonville Beachfront ImageFour Points by Sheraton Jacksonville Beachfront Image

Four Points by Sheraton Jacksonville Beachfront offers spacious oceanfront suites with private balconies, a fitness center, and direct beach access along Highway A1A. With an on-site restaurant serving hot breakfast, a convenient shuttle service, and modern amenities like free WiFi and flat-screen TVs, this beachside hotel provides a comfortable and convenient stay near Jacksonville's attractions.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Beaches Museum & History Park
Times Square Plaza

Important Info

Parking: USD 18/day
Free WiFi throughout
Pets allowed (on request)
Family friendly

Best Western Oceanfront

305 1st Street North | 3.6 mi (5.8km) to Mayo Clinic

8.5Excellent
Best Western Oceanfront ImageBest Western Oceanfront ImageBest Western Oceanfront Image

Located steps from the Atlantic Ocean, this Best Western Oceanfront offers comfortable rooms with microwaves, refrigerators, and electronic safe boxes. Guests enjoy a free hot breakfast, complimentary WiFi, and convenient access to local golfing and Jacksonville attractions.

Amenities

1 swimming pool
Non-smoking rooms
Beachfront
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Beaches Museum & History Park
Times Square Plaza

Important Info

Parking: USD 12/day
Free WiFi throughout
No pets allowed
Family friendly

SpringHill Suites By Marriott Jacksonville Beach Oceanfront

465 North First Street | 3.6 mi (5.8km) to Mayo Clinic

8.7Excellent
SpringHill Suites by Marriott Jacksonville Beach Oceanfront ImageSpringHill Suites by Marriott Jacksonville Beach Oceanfront ImageSpringHill Suites by Marriott Jacksonville Beach Oceanfront Image

SpringHill Suites by Marriott offers a beachfront oasis with direct ocean access, featuring a sun-drenched terrace, outdoor pool, and modern fitness center just steps from Neptune Beach. Guests enjoy complimentary WiFi, an on-site restaurant, and comfortable rooms with contemporary amenities, making this oceanfront property an ideal destination for business and leisure travelers.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Beachfront

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Beaches Museum & History Park
Times Square Plaza

Important Info

Parking: USD 28/day
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Hampton Inn Oceanfront Jacksonville Beach

1515 First Street North | 4 mi (6.4km) to Mayo Clinic

8.5Excellent
Hampton Inn Oceanfront Jacksonville Beach ImageHampton Inn Oceanfront Jacksonville Beach ImageHampton Inn Oceanfront Jacksonville Beach Image

This beachfront Hampton Inn offers stunning Atlantic Ocean views with a unique outdoor pool featuring four waterfalls and a relaxing hot tub. Guests enjoy convenient amenities like free parking, modern rooms with 55-inch flat-screen TVs, and on-site dining at the Oasis Grill and Tides Oceanfront Tiki Bar.

Amenities

1 swimming pool
Fitness centre
Non-smoking rooms
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Sleiman North Shopping Center
Times Square Plaza

Important Info

Parking: USD 18/day
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Fairfield Inn And Suites Jacksonville Beach

1616 North First Street | 4 mi (6.4km) to Mayo Clinic

8.3Very Good
Fairfield Inn and Suites Jacksonville Beach ImageFairfield Inn and Suites Jacksonville Beach ImageFairfield Inn and Suites Jacksonville Beach Image

Nestled near Jacksonville Beach, this Fairfield Inn offers comfortable rooms, a refreshing outdoor pool, and a hot tub for relaxing after beach adventures. Guests enjoy free WiFi, a convenient business center, and a hearty American breakfast to start the day right.

Amenities

1 swimming pool
Fitness centre
Non-smoking rooms
Facilities for disabled guests

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Sleiman North Shopping Center
Times Square Plaza

Important Info

Parking: USD 12/day
Free WiFi throughout
Pets allowed (charges apply)
Family friendly

Courtyard By Marriott Jacksonville Beach Oceanfront

1617 North First Street | 4 mi (6.4km) to Mayo Clinic

8.3Very Good
Courtyard by Marriott Jacksonville Beach Oceanfront ImageCourtyard by Marriott Jacksonville Beach Oceanfront ImageCourtyard by Marriott Jacksonville Beach Oceanfront Image

Situated directly on Jacksonville Beach, this oceanfront Courtyard hotel offers stunning coastal views, a fitness center, and comfortable rooms with balconies and modern amenities like flat-screen TVs and free WiFi. The Bistro serves Starbucks coffee, light appetizers, and evening drinks, providing convenient dining just steps from the beach.

Amenities

1 swimming pool
Non-smoking rooms
Fitness centre
Beachfront

Nearby

Neptune Beach
Timucuan Ecological Historical Preserve
Sleiman North Shopping Center
Times Square Plaza

Important Info

Parking: USD 18/day
Free WiFi throughout
Pets allowed (charges apply)
Family friendly
Olga Melnikova's profile

Olga Melnikova

Olga, a hospitality graduate with 10+ years of experience in hotels and travel blogging, has explored Europe extensively and shares expert travel insights.

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Post was updated on July 9, 2025

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